Investigation of primary microcephaly in Bushehr province of Iran: novel STIL and ASPM mutations.

To the Editor : Microcephaly is a condition which is defined by head circumference 3 SDs below the ageand sex-matched mean because of the reduced brain size (1, 2). Affected individuals suffer intellectual disability (ID) from mild to severe with any abnormalities or dysmorphic features. (1, 2). So far, eight autosomal recessive primary microcephaly (MCPH ) loci (MCPH1–MCPH8) have been mapped and MCPH genes have been identified for seven of them (3, 4).